Genes encoding proteins containing this domain include ADAR and ZBP1.
The presence of DNA anywhere other than the nucleus or mitochondria is perceived as a DAMP and triggers responses mediated by TLR9 and DAI that drive cellular activation and immunoreactivity.
For example, it was shown that β-actin zipcode binding protein 1 (ZBP1) - dependent dendritic mRNA transport contributes to proper dendritic branching.
Upon export from the nucleus the mRNA associates with ZBP1 and the 40S subunit.
ZBP1 |