Rivers of both Ecuador and Peru empty in the Gulf of Guayaquil, like the Guayas River, the Jubones River, the Zarumilla River and the Tumbes River.
The largest towns on its banks are Huaquillas, in the Ecuadorian province of El Oro, and Aguas Verdes in the Tumbes Region of Peru; both towns are connected by an international bridge.
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Morphologically, four zones can be defined in the region: the delta of the Tumbes and Zarumilla rivers; an alluvial plain north of the Tumbes River, with dry, low-depth ravines; ancient terraces that have been strongly eroded in the Máncora area; and the Amotape mountain range in the east and south, ending at El Barco Mountain.