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The increased chloride conductance drives the membrane potential towards the reversal potential of the Cl¯ ion which is about –65 mV in neurons, inhibiting the firing of new action potentials.
The project was to research action potential in the Algae Nitella, and the parenchama cells of the Mimosa pudica to determine their sensitivity to various external stimuli.
The dual effect of seletracetam is an overall decrease in the amount of action potential due to binding at N-type channels, which prevents over-excitation of the neuron, as well as a decrease in neurotransmitter release as a product of cellular excitation due to the interaction of the drug with SV2A, which reduces the spread of excitation to nearby cells.