The increased chloride conductance drives the membrane potential towards the reversal potential of the Cl¯ ion which is about –65 mV in neurons, inhibiting the firing of new action potentials.
Mutations in the calcium channel α subunit encoding gene CACNA1H and the GABA receptor γ subunit encoding gene GABRG2 yield susceptibility for CAE.
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Linkage of this disorder has been shown to mutations in the genes GABRA1, CACNB4, CLCN2, GABRD2, EFHC1, and EFHC2.
Lanthanum acts at the same modulatory site on the GABA receptor as zinc- a known negative allosteric modulator.
The granule cells express a different set of mature receptors at this stage including, GC5 and GABA receptors.
receptor | LDL receptor | Receptor (biochemistry) | Continuous erythropoietin receptor activator | GABA receptor | Epidermal growth factor receptor | NMDA receptor | Sensory receptor | receptor (biochemistry) | metabotropic glutamate receptor | GABA transaminase | 5-HT2A receptor | VLDL receptor | TGF beta receptor 2 | receptor antagonist | epidermal growth factor receptor | 5-HT receptor | RAR-related orphan receptor alpha | Metabotropic glutamate receptor 5 | Metabotropic glutamate receptor 2 | G protein-coupled receptor | AMPA receptor | Adenosine A1 receptor | Toll-like receptor | TNF receptor associated periodic syndrome | taste receptor | Sigma-1 receptor | Receptor antagonist | Receptor activity-modifying protein | Pancreatic polypeptide receptor 1 |