Furthermore mice that are in addition engineered to convert oligomers into plaques (APPE693Q X PS1ΔE9), are no more impaired than the oligomer only mice.
Animal studies indicate that volatile anaesthestics may augment the pathological processes of Alzheimer's Disease by affecting amyloid-beta processing.
Beta | Tau Beta Pi | Phi Beta Sigma | beta | Zeta Beta Tau | TGF beta 1 | Beta Gamma Sigma | The Beta Band | Tau Beta Sigma | Phi Beta Kappa Society | Beta Israel | TGF beta receptor 2 | National Beta Club | Beta (plant) | Beta (letter) | Beta-Hexachlorocyclohexane | Beta Flight | Beta Alpha Psi | VHS or Beta | Steroid 11-beta-hydroxylase | Gamma Phi Beta | Epoetin beta | Beta (typeface) | Beta Sigma Phi | Beta-galactosidase | beta decay | Beta Crucis | Beta Centauri | Beta amyloid | Alpha-Beta |
Hallmarks of Alzheimer's disease (AD) are impairment of cognition, aggregation of β-amyloid peptide (Aβ), neurofibrillary degeneration, loss of neurons with accelerated atrophy of specific brain areas, and decrease of synapse number in surviving neurons.
In animal models, ZM-241,385 has been shown to protect against beta amyloid neurotoxicity and therefore may be useful as a treatment for Alzheimer's disease.