In Alien 3, Ellen Ripley, the main heroine of the Alien franchise, learns that she has an unborn alien queen inside of her, which the Weyland-Yutani company plan to exploit as a bioweapon.
During the first story of the Brand New Day, Mister Negative first comes into conflict with Spider-Man when he makes a power play toward taking control of New York's criminal underworld by attempting to wipe out all existing members of the Karnelli and Maggia crime families using a DNA specific bioweapon called the "Devil's Breath".
Meanwhile, R.I.P.L.E.Y. is led to believe that Philadelphia has been hit by a bioterrorist attack and decides to halt the spread of the bioweapon by hijacking a Predator drone with missiles and a nuclear warhead on board and use it to destroy the city.