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; Cell biology: If the properties of the cell wall are more or less the same everywhere, it is said to be isotropic.
Capsulan is thought to be synthesised in the Golgi and then secreted through the decapore (a specialised circle of 10 pores through the cell wall).
The encrustation of the cell wall by the material constituting the Casparian strip presumably blocks the submicroscopic capillaries in the wall.
It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
In fact, this is close to the cell division of cell wall-less bacteria, such as Mycoplasma.
2-Epimerase was discovered as a target because it was one of the enzymes in the biosynthetic pathway for synthesizing an essential neutral polysaccharide in the cell wall of B. anthracis (Glu:Gal-NAc:Man-NAc at a 3:2:1 ratio).
Working with David Miller, he began to study Chlamydomonas and found that a significant amount of the cell wall consisted of extensin.
DNA and cell wall formation are also negatively impacted to a lesser degree.
Peptidoglycan, a polymer consisting of sugars and amino acids that forms a bacterial cell wall