A mutation in the gene GCH1, which encodes the enzyme GTP cyclohydrolase I, disrupts the production of BH4, decreasing dopamine levels (hypodopaminergia).
According to Jesse Boykins III, "I was inspired to name the album Dopamine: My Life On My Back based on the series of songs I was writing. They all put me in a mood that I knew could be explained. I researched love, chemical love, and addiction and the word Dopamine was the end result. Dopamine is an endorphine in your body that makes you feel 'in Love'. It is also released when your addicted to something. Addicted ... to Love."
Dopamine is a chemical in the brain which affects adrenalin and the functions of memory, attention, and problem-solving.
Dopamine | dopamine | Dopamine receptor D4 | dopamine receptor D4 | Dopamine receptor D3 | Dopamine receptor | Dopamine hypothesis of schizophrenia |
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AAAD, or DOPA decarboxylase, DDC).
A-77636, a selective dopamine receptor D1 agonist
The use of carbidopa seems counter-intuitive in Parkinson's disease (PD) in that it prevents DDC conversion of levodopa/L-DOPA to dopamine.
An influential theory, known as the Dopamine hypothesis of schizophrenia, proposed that a malfunction involving dopamine pathways was the cause of (the positive symptoms of) schizophrenia.
Agonism of D2sh receptors inhibits dopamine release; antagonism increases dopaminergic release.
Previous studies have demonstrated that the opiate reward is mediated by a dopamine-independent reward system in nondependent animals, and by a dopamine-dependent reward system in dependent animals.
Dopamine related genes linked to psychosis in this way include COMT, DRD4, and AKT1.
Shumaker founded Dopamine as a cassette-only indie label in 1995 and merged with Maniatis' label Amalagate Records in 2000.
Similar situation was seen when the macaques were injected with MPTP injection as it reduces the level of Dopamine in the DLPFC.
"Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress."
In addition, Ets factors, e.g. the vertebrate Etv1 and the invertebrate Ast-1, have been shown to be important players in the specification and differentiation of dopaminergic neurons in both C. elegans and olfactory bulbs of mice.
His first EP, Dopamine: My Life On My Back EP was released February 14, 2008 and his follow up The Beauty Created LP was released November 25, 2008 through NomaDic MuSic.
Dantrolene has been used when needed to reduce muscle rigidity, and more recently dopamine pathway medications such as bromocriptine have shown benefit.
Prosavin uses Oxford BioMedica's Lentivector delivery system to transfer three genes, aromatic amino acid dopa decarboxylase, tyrosine hydroxylase and GTP-cyclohydrolase 1, to the striatum in the brain, reprogramming transduced cells to secrete dopamine.
Dopamine receptor blockade (NMS) has a slow onset and typically evolves over several days after administration of a neuroleptic drug and responds to dopamine agonists such as bromocriptine.
Sikth, PDHM, Electric Eel Shock, Aconite Thrill, Johnny Truant, JOR, The Blueprint, Hiding With Girls, Frowser, Twoday Rule, 17 Stitches, Ako, Kenisia, Project Abner, SiZE, Beecher, Lamb Quartet, Dopamine, Joski, coMA Kai, Needleye, Blind Eye Policy, Fog Donkey, Fourway Kill, My Pet Junkie, The Mirrormen, Severed State, Planet of Women, One Man Down, Lost for Words.