Hypoglycemia, an unusually low concentration of sugar in the blood
APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.
In 2008, the UK charity Diabetes UK announced that they were helping to fund a project, performed by researchers at Queen's University Belfast and the University of Lincoln, looking at whether dogs really can detect hypoglycemia.
Thanks to the presence of the glucose-6-phosphatase enzyme (G6PC), the hepatocytes are capable to turn G6PC to glucose and release it to blood so as to prevent the hypoglycemia.