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Professor Dieli’s research has covered several aspects of human immunology: delayed-type hypersensitivity responses, immune response against Mycobacterium tuberculosis and cancer immunotherapy.
Imiquimod or Aldara, a prescription medication that acts as an immune response modifier
Clonal Anergy theory, proposed by Nossal, in which self-reactive T- or B-cells become inactivated in the normal individual and cannot amplify the immune response.
Variable surface glycoproteins allow the sleeping sickness Trypanosoma parasite to escape the immune response of the host.
More modern uses of saponins in biotechnology are as adjuvants in vaccines: Quil A and its derivative QS-21, isolated from the bark of Quillaja saponaria Molina, to stimulate both the Th1 immune response and the production of cytotoxic T-lymphocytes (CTLs) against exogenous antigens make them ideal for use in subunit vaccines and vaccines directed against intracellular pathogens as well as for therapeutic cancer vaccines but with the aforementioned side-effects of hemolysis.
#Non-specific immunostimulants act irrespective of antigenic specificity to augment immune response of other antigen or stimulate components of the immune system without antigenic specificity, such as adjuvants and non-specific immunostimulators.
Platts-Mills has researched the immune response to a range of allergens including those from pollens, dust mites, the fungus Trichophyton, and domestic cats.