The viral envelope, obtained by budding through membranes of the ER and/or Golgi apparatus, invariably contains two virus-specified (glyco)protein species, S and M. Glycoprotein S comprises the large surface projections, while the M protein is a triple-spanning transmembrane protein.
Variable surface glycoproteins allow the sleeping sickness Trypanosoma parasite to escape the immune response of the host.
Glycoprotein growth factors regulate the proliferation and maturation of the cells that enter the blood from the marrow, and cause cells in one or more committed cell lines to proliferate and mature.
His areas of expertise includes a major contribution to the discovery of P-glycoprotein (MDR1, ABCB1), the multidrug resistance efflux transporter associated with clinical resistance to anti-cancer agents.
miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.
He is best known for his discovery of P-glycoprotein, one of the proteins responsible for multidrug resistance.
P-glycoprotein | glycoprotein | P-selectin glycoprotein ligand-1 | Glycoprotein | Variable surface glycoprotein | Glycoprotein IIb/IIIa |
Intrinsic factor, a glycoprotein produced by the parietal cells of the stomach, which is necessary for the absorption of vitamin B12
A polyclonal caprine antibody is in phase II human clinical trials that targets, among others sites, the GP41 transmembrane glycoprotein.
Fibronectin, a glycoprotein involved in cell adhesion and growth
Hypericum extract, by inducing both the CYP3A4 and the P-glycoprotein (P-gp), can reduce the plasma concentrations of different antineoplastic agents such as imatinib, irinotecan and docetaxel, thus reducing the clinical efficacy of these drugs.
Inhibins are heterodimeric glycoproteins composed of an α subunit (INHA) and one of two homologous, but distinct, β subunits (βA or βB, this protein).
Membrane Inhibitor of Reactive Lysis, CD59, a cell surface glycoprotein that inhibits complement-mediated lysis.
A frequently used protein is the glycoprotein G of the Vesicular stomatitis virus (VSV), short VSV-G.
INn Trypanosoma congolense, in vitro analyses of the incorporated sugars after hydrolysis of the glycoprotein showed that glucosamine and mannose are utilized in the biosynthesis of the carbohydrate moiety directly whereas galactose was converted possibly to other intermediates before being incorporated into the antigen.
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Combinatorial processes increase the diversity of variable surface glycoproteins.
In the mouse (the best characterised mammalian system), the zona glycoprotein, ZP3, is responsible for sperm binding, adhering to proteins on the sperm plasma membrane (GalT).