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Lymphocytes move to the epidermis where they reside as a memory T cells, they will thus be activated and will trigger inflammatory response.
Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite.
The immune complexes, which consist of DNA and anti-DNA, cause an inflammatory response as well as a disruption of the blood–brain barrier.
It dampens the inflammatory response during bacterial invasion by suppressing the TNF-α-Receptor-associated factor 6 (TRAF6)-mediated signalling pathway.