Human leukocyte antigen | Leukocyte receptor tyrosine kinase | Leukocyte extravasation | Human Leukocyte Antigen | human leukocyte antigen |
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues.
HLA-DQ4, a Human leukocyte antigen HLA-DQ serotype that recognizes the DQB1*04 gene products
The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins.
LFA-1 is part of the family of leukocyte integrins that are recognised by their common β-chains (β2, CD18).
Patients have markedly reduced whole-body cholesterol biosynthesis associated with suppressed hepatic, ileal, and mononuclear leukocyte hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase), the rate-controlling enzyme in the cholesterol biosynthetic pathway.