In 1960 the Austrian biochemist Oleh Hornykiewicz, while at the University of Vienna, examined results of autopsies of patients who had died with Parkinson's disease.
levodopa |
It is used in the management of Parkinson's disease in combination with L-DOPA (levodopa) as co-beneldopa (BAN), under the brand names Madopar in the UK and Prolopa in Canada, both made by Roche.
The use of carbidopa seems counter-intuitive in Parkinson's disease (PD) in that it prevents DDC conversion of levodopa/L-DOPA to dopamine.
L-DOPA (levodopa), used in the treatment of Parkinson's disease
Joseph Sharkey, whose work at the hospital included the early trials of levodopa in Parkinsonism, cared for 200 post-encephalitic Parkinsonism patients shortly after the second world war.
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After the war, 200 post-encephalitic Parkinsonism patients were cared for at the hospital by consultant geriatrician and former general practitioner Joseph Sharkey, whose work at the hospital included the early trials of levodopa in Parkinsonism.