In 2011 he received the Canada Gairdner Award from the Gairdner Foundation, together with Howard Cedar and Adrian Peter Bird, for their "pioneering discoveries on DNA methylation and its role in gene expression."
Creatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine.
The passive process takes place in the absence of methylation of newly synthesised DNA strands by DNMT1 during several replication rounds (for example, upon 5-Azacytidine treatment).
ChIP-on-chip assays, which is based on the ability of commercially prepared antibodies to bind to DNA methylation-associated proteins like MeCP2.
Epigenomics has licensed the SEPT9 biomarker and certain DNA methylation technologies to Quest Diagnostics and ARUP Laboratories in the US, as well as Warnex Laboratories in Canada.
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Epi proColon - a test to measure the methylation status of the SEPT9 promoter in plasma as an aid in early detection of colon cancer.
In 2011 he received the Canada Gairdner Award from the Gairdner Foundation, together with Aharon Razin, for their "pioneering discoveries on DNA methylation and its role in gene expression."
Petunidin could form in the exocarp of fruits from delphinidin, with an anthocyanin flavonoid O-methyltransferase (Catechol-O-methyl transferase) catalyzing the B-ring methylation and S-Adenosyl-L-methyl-3H methionine being the methyl group donor.
The main focus of his experimental work was the epigenetic control of gene expression by DNA methylation in CHO cells.
snoR12 was identified by computational screen of the rice Oryza sativa genome and is predicted to acts as a methylation guide for 25S ribosomal RNA in plants.
snoR160 was identified by computational screening of the rice Oryza sativa and is predicted to acts as a methylation guide for 25S ribosomal RNA in plants.
snoR41 was identified by computational screening the rice Oryza sativa genome and is predicted to act as a methylation guide for 18S and 25S ribosomal RNA (rRNA).
snoR66 was identified by a computational screening of the rice Oryza sativa genome and is proposed to acts as a methylation guide for 18S ribosomal RNA in plants.
The enzymes from Oryza sativa (ROMT-15 and ROMT-17) catalyses the stepwise methylation of tricetin to its 3'-mono- and 3',5'-dimethyl ethers.