Finally, DNMT2 (TRDMT1) has been identified as a DNA methyltransferase homolog, containing all 10 sequence motifs common to all DNA methyltransferases; however, DNMT2 (TRDMT1) does not methylate DNA but instead methylates cytosine-38 in the anticodon loop of aspartic acid transfer RNA.
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The Restriction enzyme DpnI can recognize 5'-GmeATC-3'sites and digest the methylated DNA.
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ChIP-on-chip assays, which is based on the ability of commercially prepared antibodies to bind to DNA methylation-associated proteins like MeCP2.
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In 2011 he received the Canada Gairdner Award from the Gairdner Foundation, together with Howard Cedar and Adrian Peter Bird, for their "pioneering discoveries on DNA methylation and its role in gene expression."
Epigenomics has licensed the SEPT9 biomarker and certain DNA methylation technologies to Quest Diagnostics and ARUP Laboratories in the US, as well as Warnex Laboratories in Canada.
In 2011 he received the Canada Gairdner Award from the Gairdner Foundation, together with Aharon Razin, for their "pioneering discoveries on DNA methylation and its role in gene expression."
The main focus of his experimental work was the epigenetic control of gene expression by DNA methylation in CHO cells.