Crowe sign, or Crowe's sign, a medical sign that is used in the diagnosis of neurofibromatosis
Another example is neurofibromatosis, where patients with the same genetic mutation show different signs and symptoms of the disease.
These include, in descending order of frequency, neurofibromatosis Recklinghausen (NF-1), Carney's triad (gastric GIST, pulmonary chondroma and extra-adrenal paraganglioma), germline gain-of-function mutations in c-Kit/PDGFRA, and the Carney-Stratakis syndrome.