The subtilisin-like proprotein convertases (SPC) Furin (Spc1) and PACE4 (Spc4) recognize a specific sequence of the precursor of nodal protein and cleaves it to form the mature nodal ligand.
Wnt signaling pathway | NODAL | Hedgehog signaling pathway | Signaling System No. 5 | Nodal | nodal | Widescreen signaling | Single-frequency signaling | Signaling lymphocytic activation molecule | Semaphore Flag Signaling System | nodal signaling | Nodal analysis | Next Steps in Signaling | Low-voltage differential signaling | John Howard Nodal | hedgehog signaling pathway | Akt/PKB signaling pathway |
Many signaling pathways contribute to this reorganization, including BMP, FGF, nodal, and Wnt.
Furthermore, in zebrafish, Nodal signaling is required for differentiation of medial floor plate cells whereas Shh is expendable.