The major molecular pathways involve members of the Wnt, Notch, BMP, FGF8 and GATA families.
Studying both signaling pathways and motifs allows a deeper understanding of the similarities and differences of many biological functions, processes, and structures among organisms.
The encoded protein is a negative regulator of the Wnt signaling pathway.
Many signaling pathways contribute to this reorganization, including BMP, FGF, nodal, and Wnt.
In the fruit fly Drosophila melanogaster, segment polarity genes help to define the anterior and posterior polarities within each embryonic parasegment by regulating the transmission of signals via the Wnt signaling pathway and Hedgehog signaling pathway.
The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway.
Wnt signaling pathway | Hedgehog signaling pathway | Bow River pathway | Signaling System No. 5 | Pathway Studios | Pathway Genomics | Widescreen signaling | The Small Molecule Pathway Database | Single-frequency signaling | Signaling lymphocytic activation molecule | Semaphore Flag Signaling System | Pentose phosphate pathway | nodal signaling | Next Steps in Signaling | neural pathway | Low-voltage differential signaling | hedgehog signaling pathway | Akt/PKB signaling pathway |
Anterior-posterior patterning by Cerberus is accomplished by acting as an antagonist to nodal, bmp, and wnt signaling molecules in the anterior region of the vertebrate embryo during gastrulation.
Activation of various secreted factors (Vg1, Nodal, Wnt8C, FGF8 and Chordin) and transcription factors (Brachyury and Goosecoid) adjacent to the site of streak formation is required for this process.
Working with the Xenopus system, Davidson et al. screened for proteins that can regulate the Wnt signaling pathway by interacting with the Wnt receptor LRP.