The synthesis starts from benzvalene (1) and 4-phenyltriazolidone, which is a strong dienophile.
DMT1 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - a neurotoxin widely used experimentally to produce Parkinsonian symptoms.
The Fries rearrangement, named for the German chemist Karl Theophil Fries, is a rearrangement reaction of a phenyl ester to a hydroxy aryl ketone by catalysis of Lewis acids.
The λ5-iodanes such as the Dess-Martin periodinane have square pyramidal geometries with 4 heteroatoms in basal positions and one apical phenyl group.
F. S. Kipping coined the word "silicone" in 1901 to describe polydiphenylsiloxane by analogy of its formula, Ph2SiO (Ph stands for phenyl, C6H5), with the formula of the ketone benzophenone, Ph2CO.