Fraction S2 contains two phospholipases A2 — PLA2 I and PLA2 II; fraction S3 contains four cytotoxin homologues — maticotoxins A, C, D1 and D2; and fractions S4 and S5 contain a large amount (about 1 mg/specimen) of adenosine with smaller amounts of inosine and guanosine.
The venom of the Equatorial spitting cobra exhibited the common characteristic enzymatic activities of Asiatic spitting cobra venoms: low protease, phosphodiesterase, alkaline phosphomonoesterase and L-amino-acid oxidase activities, moderately high acetylcholinesterase and hyaluronidase activities and high Phospholipase B | phospholipase A2 | phospholipase | Phospholipase A2 | N-acyl phosphatidylethanolamine-specific phospholipase D | lipoprotein-associated phospholipase A2 | specific phospholipase D | Phospholipase cleavage sites. Note that an enzyme that displays both PLA1 and PLA2 activities is called a ''Phospholipase B | phospholipase C | Lipoprotein-associated phospholipase A2 | Similar
He became involved in a project financed mostly by Menarini Pharmaceuticals, aimed at the rationalization of the biochemical activity of a number of phospholipase A2 (PLA2) enzymes from different sources and, ultimately, at the design of novel inhibitors of human synovial fluid PLA2 tagged as anti-inflammatory agents.
These target genes encode proteins such as cyclooxygenase, NO synthase, phospholipase A2, tumor necrosis factor, transforming growth factor beta, ICAM-1, and a number of other pro-inflammatory proteins.
Varespladib methyl (also known as A-002, formerly LY333013 and S-3013) is a secretory phospholipase A2 (sPLA2) inhibitor formerly under development by Anthera Pharmaceuticals as a treatment for acute coronary syndrome (ACS).
An enzyme that displays both phospholipase A1 and phospholipase A2 activities is called a Phospholipase B (see main article on phospholipases).
M-type phospholipase A2 receptor is a major antigen in idiopathic membranous nephropathy.