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The first, historical strand is based on the real-life Hungarian-born Ignaz Philipp Semmelweis, a doctor working in 19th-century Vienna, who realised that the spread of child-bed or puerperal fever could be prevented if doctors would wash their hands between patients.
He later became severely depressed over the number of women (including a beloved cousin) who had died from puerperal fever due to unsanitary obstetrical practices, and on August 8, 1848, Michaelis committed suicide in Lehrte, Germany.