It was also observed that increasing the bulk of the R group on the diketone and using methoxy-substituted anilines leads to the formation of 2-CF3-quinolines.
This reaction is also known as the Skraup-Doebner-Von Miller quinoline synthesis, and is named after the Czech chemist Zdenko Hans Skraup (1850–1910), and the Germans Oscar Döbner (Doebner) (1850–1907) and Wilhelm von Miller (1848–1899).
In 2005 he and his team published a discovery about a new di-Aryl-Quinoline-based drug (R207910) which promises a shorter and simpler treatment for Tuberculosis (TB).