-{BRL-54443}-, agonist of 5-HT1E and 5-HT1F serotonin receptors
He found new methods for the synthesis of pyrylium salts (Balaban-Nenitzescu-Praill synthesis), of carbenes, triptamine, serotonin, two new syntheses for the indole nucleus, and a new method of polymerisation of ethylene.
The head-twitch response (HTR) is a rapid side-to-side head movement that occurs in mice and rats after the serotonin 5-HT2A receptor is activated.
5-Hydroxyindoleacetic acid (5-HIAA), a metabolite of serotonin used to diagnose carcinoid tumors
Impulsive behavior, and especially impulsive violence predisposition has been correlated to a low brain serotonin turnover rate, indicated by a low concentration of 5-Hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF).
Triptans - there have been rare postmarketing reports of hyperserotonergia (serotonin syndrome).
The output of the SCG, stimulates NE receptors (β) in the pineal gland which produces N-acetyltransferase, causing production of melatonin from serotonin.
In 1963 Tyler and Smith found that this mushroom contains serotonin, 5-HTP and 5-hydroxyindoleacetic acid.
In 2002 a research group at the University of Oslo discovered that muscles from the ventricle of failing hearts have increased responsiveness to serotonin.
Crane's discovery is also used in blockbuster drugs, such as the SSRI Prozac, which treat depression by inhibiting the Na/serotonin cotransporters in the brain.
The term
Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonergic activity at central nervous system (CNS) and peripheral serotonin receptors.
Tryptophan and 5-hydroxy-tryptophan, for instance, can be used to help the body replenish serotonin levels in the brain after the use of MDMA, and vitamin supplements are appropriate for users of stimulants such as amphetamine.
Gonzalez-Maeso, J., R.L. Ang, T. Yuen, P. Chan, N.V. Weisstaub, J.F. Lopez-Gimenez, M. Zhou, Y. Okawa, L.F. Callado, G. Milligan, J.A. Gingrich, M. Filizola, J.J. Meana, and S.C. Sealfon, Identification of a serotonin/glutamate receptor complex implicated in psychosis.
The binding of platelets to the sub-endothelial collagen stimulates the secretion of ADP, TXA2, and serotonin present in the platelet granules.
Evidence was found that an accumulation of serotonin using VMAT1 and TPH1 allowed for the subsequent release of serotonin when exposed to cold temperatures.
Fluoxetine (Prozac), euphemistically referred to as Vitamin P, a selective serotonin reuptake inhibitor (SSRI) used for depression and various mental disorders
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Paroxetine (Paxil), euphemistically referred to as Vitamin P, a selective serotonin reuptake inhibitor (SSRI) used for depression and anxiety disorders