Schoppe obtained the favour of Pope Clement VIII, and distinguished himself by the virulence of his writings against the Protestants.
Frequently grafting his ideas onto subjects taken freely from Uncle Remus, Alice's Adventures in Wonderland, and the works of Dickens and Shakespeare, Gould used these literary vehicles with extraordinary dexterity and point, but with a satire that was not unkind and with a vigour from which bitterness, virulence and cynicism were notably absent.
A two-component system, involving histidine kinase and a variable response regulator protein, may be critical to the virulence of some fungal strains such as Candida albicans, which is often responsible for causing candidiasis in immunocompromised persons.
An ongoing or lingering pandemic may amount to a humanitarian crisis, especially where there are increasing levels of virulence, or rates of infection as in the case of AIDS, bird flu or Tuberculosis.
Paul W. Ewald has explored the relationship between virulence and mode of transmission.
Shiga toxins (Stx) are the primary virulence factors in enterohaemorrhagic E. coli but EHEC produces several other virulence factors capable of damaging the vascular endothelium in EHEC infections.