During the 1990s it was featured in the BBC television series Children's Hospital.
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Alder Hey Children's NHS Foundation Trust runs Alder Hey Children's Hospital a children's hospital in West Derby, Liverpool.
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The hospital is currently being rebuilt in neighbouring Springfield Park in a £237 million pound scheme.
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During the First World War, the United States Army established Camp Hospital 40 on the site, operated by Hospital Unit Q and, subsequently, Unit W. American sources commonly refer to Alder Hey as being within Liverpool's Knotty Ash area.
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The Trust is a Centre of Excellence for specialist health care to women and their families in Birmingham and the West Midlands.
The charity's patrons include Michael Palin and England Cricketer Michael Vaughan (his wife, Nichola Shannon, works as a management accountant for the Sheffield Children's Trust).
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A third of patients come from the outside Sheffield, from all parts of the country, but especially from Barnsley, Rotherham, Doncaster, Derbyshire and Nottinghamshire.