He served as apostolic administrator of Pamplona, Spain from 1520 to 1538; that of Alessano, Italy from 1526 to 1531; that of Otranto, Italy from 1526 to 1536; that of Gerace, Italy from 1536 to 1538; that of Catanzaro, Italy briefly in 1536; that of Oppido Mamertina, Italy from 1536 to 1538 (resigning in favor of his natural son, Ascanio Cesarini, who succeeded him in that see from 1538 to 1542); and that of Cuenca, Spain from 1538 to his death.
It is home to the Sforza Cesarini Castle, originally built in 1084 but turned into a more modern fortress in the 1530s by Baldassarre Peruzzi, commissioned by Cardinal Alessandro Cesarini.
In 1532, he became embroiled in a trial, based on suspicion of being the murderer of a priest sent to Sardinia by Cardinal Alessandro Cesarini.
Alessandro Manzoni | Alessandro Volta | Alessandro Scarlatti | Alessandro Farnese | Alessandro Mendini | Alessandro Ballan | Alessandro Safina | Alessandro Del Piero | Alessandro Cagliostro | Alessandro Baricco | Alessandro | Caroline Shirley, Duchess Sforza Cesarini | Alessandro Ripellino | Alessandro Magnasco | Alessandro Gherardini | Alessandro Barsanti | Duchess Sforza Cesarini | Alessandro Vespignani | Alessandro Talotti | Alessandro Riguccini | Alessandro Peretti di Montalto | Alessandro Pasqualini | Alessandro Mussolini | Alessandro Malaspina | Alessandro Haber | Alessandro Grandi | Alessandro Galilei | Alessandro Farnese (cardinal) | Alessandro Deljavan | Alessandro Cesarini |