It was first made by Alexander Shulgin and is mentioned in his book TiHKAL, but was never tested by him.
Richard Schultes in 1941 described Mexican Native American use in a short report documenting the use dating back to Aztec times cited in TiHKAL by Alexander Shulgin.
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In their book TiHKAL, Alexander and Ann Shulgin describe it as being "an order of magnitude less potent than LSD itself".
The Library's advisory Board of Trustees included a number of eminent researchers and writers, including Chauncey Leake, Richard Evans Schultes, Albert Hofmann, Alexander Shulgin, Andrew Weil, Oscar Janiger, Ralph Metzner, Laura Huxley, Allen Ginsberg, Weston LaBarre, R. Gordon Wasson, Tod H. Mikuriya, and Lawrence Ferlinghetti.
Individuals having published information on psychedelic psychotherapy in this period include George Greer, Ann Shulgin (TiHKAL, with Alexander Shulgin), and Myron Stolaroff (The Secret Chief, about the underground therapy done by Leo Zeff) and Athanasios Kafkalides.
Ann Shulgin (b. 1931), American author and wife of Alexander Shulgin