Escalera had his first professional bout on September 4, 1970, against Bob Payzant, in Portland.
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Escalera and Argüello had a rematch, on February 4, 1979, in Rimini, and Escalera held a small lead on the judges' cards after 12 rounds.
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He lost to future world light welterweight champion Gene Hatcher in San Antonio, but he beat former world title challenger Maurice Termite Watkins at "The Battle of the Champions'" undercard in Miami, to complete his 1982 boxing campaign.
His most notable early win came against former WBC super featherweight champion Alfredo Escalera in 1982, when he won a ten-round decision.
Alfredo Andreini | Alfredo Di Stéfano | Alfredo Lim | Alfredo Alonso | José Alfredo Jiménez | Alfredo Kraus | Alfredo Alcala | Alfredo Casella | Alfredo Stroessner | Alfredo Pérez Rubalcaba | Alfredo Cristiani | Alfredo Ottaviani | Alfredo Jaar | Alfredo Astiz | José Alfredo Jiménez' tomb in Dolores Hidalgo | Alfredo Pareja Diezcanseco | Alfredo Mantica | Alfredo López Austin | Alfredo Lopez | Alfredo Keil | Alfredo Guati Rojo National Watercolor Museum | Alfredo Gil | Alfredo Escalera | Alfredo Chávez | Alfredo Castelli | Alfredo Cantu Gonzalez | Alfredo Campoli | Alfredo Angulo | José Alfredo Caires de Nobrega | Jorge Alfredo Gonzalez |
After he knocked out Camel in 8 in a rematch, countryman Ossie Ocasio won the WBA world title, becoming the second pair of Puerto Ricans to share world titles in the same division at the same time, after Alfredo Escalera and Samuel Serrano had achieved the feat in the 1970s at Jr.
Alfredo L. Escalera (born February 17, 1995) also known as Alfredo Escalera and Alfredo Escalera-Maldonado is an American baseball outfielder for the Kansas City Royals.