In the "Big Time" storyline, Alistair Smythe returns with a new metallic body armor and is hunting down all of J. Jonah Jameson's friends and families.
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However due to Superior Spider-Man (identical to Doctor Octopus scheme in "Dying Wish") having already done this, he has equipped his head with armoured plating.
Spider-Man battles various villains throughout the game - Beetle, Lizard, Mysterio, Alistair Smythe, Green Goblin, Scorpion, Venom, Doctor Octopus, and Carnage.
Alistair Edwards | Alistair Darling | Alistair Cooke | Alistair Begg | Alistair McGowan | Percy Smythe, 6th Viscount Strangford | Alistair MacLean | Alistair Graham | Alistair Beaton | Kit Smythe | Conn Smythe Trophy | Alistair Smythe | Alistair Overeem | Alistair McAlpine, Baron McAlpine of West Green | Alistair Jackson | Alistair Cockburn | Robert Smythe Hichens | Ian Alistair Mackenzie | Henry A. Smythe | Alistair Cragg | Alistair Cooke's | Alistair Campbell (poet) | Alistair Campbell | Alistair Burt | Alistair Brownlee | Alistair Browning |
Alistair Smythe eventually discovers that his father is alive with Spider-Man's help and escapes with his cryonically preserved body.