The protein encoded by this gene, ankyrin-3 is an immunologically distinct gene product from ankyrins ANK1 and ANK2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems.
Axon Idea Processor was written in Visual Prolog by Mr. Chan Bok from Singapore as a tool for computer-assisted thinking and problem solving.
When lipid diacylglycerol (DAG) binds to the C1 domain, CHN1 is transferred to the plasma membrane and negatively regulates Rho-family small GTPases RAC1 and CDC42, thus causing the morphological change of axons by pruning the ends of axon dendrites.
The demyelination and scarring of axons in the neurons of the nervous system can affect their conduction properties and seriously harm the normal communication of the brain with the rest of the body.
He was the subject of a famous 1957 radio ballad (The Ballad of John Axon), the first of the series, written by Ewan MacColl and Peggy Seeger and produced by Charles Parker.
Mossy fiber is the axon of granule cell in the dentate gyrus.
By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.
In their Nobel Prize-winning work uncovering ionic mechanism of action potentials, Alan Hodgkin and Andrew Huxley performed experiments on the squid giant axon.