Binding of Isaac, a Judaeo-Christian story where God orders Abraham to sacrifice his son Isaac
The plot involves a sect called the Abrahamites, who (according to the movie) sacrifice their first borns following an alternative interpretation of God's Will in the near-sacrifice of Isaac.
The Binding of Isaac: Rebirth is a remake of the original The Binding of Isaac.
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The Binding of Isaac: Rebirth is an upcoming remake of The Binding of Isaac developed by Nicalis and designed by Edmund McMillen (who designed the original game).
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Jewish sources identify this rock as the place mentioned in the Bible where Abraham fulfilled God's test to see if he would be willing to sacrifice his son Isaac.
Traces of other figures can also be seen including Michael fighting the dragon, the Judgment of Solomon and the Sacrifice of Isaac.