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It is an indicator of how full the circulatory system is (i.e. the volume of blood in the system compared to the capacity of the system), and is influenced by the volume of circulating blood and the smooth muscle tone in the walls of the venous system (which determines the capacity of the system).
Lead singer Kevin Matisyn suggested the name, which refers to the dye that is injected into the bloodstream to measure blood volume, which he had read in one of his medical books.
It may occur in situations with an increased blood volume, from excess of water and salt (renal pathology, excess of fluid or blood administration, treatment with retaining water steroids), chronic and severe anemia, large arteriovenous fistula or multiple small arteriovenous shunts as in Paget's disease of bone, some forms of severe hepatic or renal disorders, hyperthyroidism, beriberi.