Federico Borromeo (1564–1631), also cardinal from 1587, and archbishop of Milan from 1595, important patron of art
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Edoardo Borromeo (1822–1881), cardinal from 1868, only a titular bishop
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Saint Charles Borromeo (1538–1584), cardinal archbishop of Milan from 1564 to 1584, important person in the church
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Among his many works: an oil canvas of Una passeggiata; Petrarch induces the painter Lippo Memmi to secretly paint a portrait of Laura; Sappho meditates Suicide; Don Abbondio and the cardinal Borromeo; Victim of Primogeniture, also called Victim of the Cloister because it depicts a young nun in her death bed, dying due to the cloistered life imposed by her family; The sack and massacre of Muslims in a house in Bulgaria; and The island of Favignana.
During Cardinal Borromeo's sojourns in Rome, 1585–95 and 1597–1601, he envisioned developing this library in Milan as one open to scholars and that would serve as a bulwark of Catholic scholarship in the service of the Counter-Reformation against the treatises issuing from Protestant presses.
Corti's monument to Cardinal Borromeo was commissioned in 1861 for the plaza of the Biblioteca Ambrosiana.