According to the Institute of Medicine, there are about 116 million Americans living with chronic pain.
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The German Center for Pediatric and Adolescent Rheumatology in Garmisch-Partenkirchen (also called the 'Kinderrheumaklinik', i.e. the Pediatric Rheumatology Hospital) is the largest specialized center for the treatment of children and adolescents with rheumatic diseases and chronic pain syndromes in Europe.
Pulsed radiofrequency, neuromodulation, direct introduction of medication and nerve ablation may be used to target either the tissue structures and organ/systems responsible for persistent nociception or the nociceptors from the structures implicated as the source of chronic pain.