HLA-DQ8, an HLA-DQ receptor serotype associated with coeliac disease.
Triticeae cultivation may apply negative selection on DQ8.
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Most of American cultivars were domesticated south of the Rio Grande (exceptions are Caddo rice and Texas varigated squash, etc.).
HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9.
DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9.
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DQA1*0505, without DQ2, is found in a small percentage of coeliac disease (without DQ2 or DQ8).