X-Nico

3 unusual facts about HLA-DQ8


DQ8

HLA-DQ8, an HLA-DQ receptor serotype associated with coeliac disease.

HLA-DQ8

Triticeae cultivation may apply negative selection on DQ8.

Most of American cultivars were domesticated south of the Rio Grande (exceptions are Caddo rice and Texas varigated squash, etc.).


Dermatitis herpetiformis

It is most common in patients of northern European ancestry, and is associated with the HLA-DQ2 haplotype along with celiac disease and gluten sensitivity.

DQ4

HLA-DQ4, a Human leukocyte antigen HLA-DQ serotype that recognizes the DQB1*04 gene products

DQ7

HLA-DQ7, an HLA-DQ receptor serotype in which the beta chain is encoded by DQB1*0301 gene.

Global Information Network Architecture

GINA was developed to become a High Level Architecture (HLA) for System Fusion Networks (SFN) as an interoperable and multi-level security ("MLS") engine.

Herpesviridae

They have also been shown to play a role in downregulating MHC I and MHC II and up regulating HLA-G (non-classical MHC I).

History and naming of human leukocyte antigens

Classification of C antigens is still ongoing, and they have retained the name Cw as many serotypes have not been developed.

HLA DR3-DQ2

HLA DR3-DQ2 is the serotypic representation of a HLA-DRB1:DQA1:DQB1

The DR3-DQ2 haplotype is notable because of the very strong linkage between genes that extends into the HLA-A, -B and -C regions of the HLA gene complex in northern and northwestern Europe.

Hla Myint Swe

In June 1999 Hla Myint Swe met the staff of Myanmar Airways International, urging them to work hard, seek ways to earn more foreign exchange, be loyal to the State, take innovative measures, uphold national prestige and integrity and make all-out efforts for development of the State.

HLA-B46

When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia.

It is the result of a recombination event between B62(B*1501) and an HLA-C allele within Asia.

HLA-DP

DPα and DPβ are encoded by two loci, HLA-DPA1 and HLA-DPB1, that are found in the MHC Class II (or HLA-D) region in the Human Leukocyte Antigen complex on human chromosome 6 (see protein boxes on right for links).

HLA-DQ3

HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9.

DQB1*0304 is similar in structure and function to DQB1*0301 generally considered to be HLA-DQ7

HLA-DQ6

For DQ6, however, cis-isoform pairing only occurs with DQ1 α-chains.

HLA-DQ7

DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9.

DQA1*0505, without DQ2, is found in a small percentage of coeliac disease (without DQ2 or DQ8).

HLA-DR1

HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes.

HLA-DR10

HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes.

HLA-DR13

HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products.

HLA-DR16

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products.

HLA-DR18

HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products.

HLA-DR2

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group.

HLA-DR5

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

HLA-DR51

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.

HLA-DR6

HLA-DR6 (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.

HLA-DR8

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

HLA-DR9

HLA-DR09 (DR9) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

KLRD1

The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Ludu U Hla

An old school friend of Daw Amar's father, he was famous for his excellent adaptations of Sir Arthur Conan Doyle's Sherlock Holmes and Brigadier Gerard as well as his translations of H. Rider Haggard's Alan Quartermain novels and was arrested at the same time as U Hla but he was to remain in Mandalay Prison for the duration.

Manchester High School for Girls

Julia Bodmer, nee Pilkington, Manchester High School pupil: 1945 - 1953, discovered the details of the Human leukocyte antigen (HLA) with genetic differences causing transplant rejection, and was married to Sir Walter Bodmer, who was the first Professor of Genetics at the University of Oxford, Chancellor of the University of Salford from 1995 to 2005 and Principal from 1996 to 2005 of Hertford College, Oxford

NFX1

The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro.

Peripheral stem cell transplantation

The transplantation may be autologous (an individual's own blood cells saved earlier), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin).

Persistent polyclonal B-cell lymphocytosis

Among them, it is associated with a particular genetic variant of the human leukocyte antigen called HLA-DR7.

Polymyalgia rheumatica

People who have the HLA-DR4 type of human leucocyte antigen appear to have a higher risk of polymyalgia rheumatica.

Signal peptide peptidase

A nine amino acid-long cleavage fragment is then presented on HLA-E receptors and modulates the activity of natural killer cells.

Singu Min

Singu was born Min Ye Hla, the eldest son to Prince of Myedu (later King Hsinbyushin) and his first wife at the Royal Palace in Ava on 10 May 1756.

Xmap

xMAP (Multi-Analyte Profiling) technology is a multiplex assay format, patented by Luminex Corporation, using a panel of microspheres internally doped with two fluorescent dyes to produce up to 100 different bead identities that can be used in various applications - from HLA genotyping by oligonucleotide probe hybridization to serological profiling e.g. antibody diversity profiling, antibody identification or histocompatibility screen etc


see also