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Apparently, this title was awarded again by king Charles I of Spain, a.k.a. Holy Roman Emperor Charles V to Rodrigo Pacheco.
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He was the eldest son of the well known literary man of the 15th century, Íñigo López de Mendoza y Lasso de la Vega, (1398–1458), 1st marquis of Santillana since 1447.
The title Duke of the Infantado (Spanish Duque del Infantado) was granted to Diego Hurtado de Mendoza y Figueroa, son of Íñigo López de Mendoza, 1st Marquis of Santillana, by the Catholic Monarchs, Ferdinand II of Aragon and Isabella I of Castile, on 22 July 1475.
Diego Hurtado de Mendoza (1503-1575), Spanish novelist, poet, diplomat and historian
There is a cheap facsimile edition of another contemporary book in which he polemized with the author, albeit it was no printed at the time of the morisco´s war in the Alpujarra by Diego Hurtado de Mendoza: GUERRA DE GRANADA (FACSIMIL, edition of 1842), de HURTADO DE MENDOZA, DIEGO , 15.0x21.0 cm , 215 pages , softcover, ISBN 978-84-9761-157-2
he was the partisan of the Princess Isabella, afterwards queen, while his eldest brother Diego Hurtado de Mendoza, 2nd marquis of Santillana, remained however faithful to king Henry IV of Castile, till his rather controverted death in December 1474.
Among his direct descendants are major Spanish poets and writers Inigo Lopez de Mendoza, Jorge Manrique and Diego Hurtado de Mendoza.