He founded a number of new Spanish settlements and cities on the island, first Baracoa in 1511 and then most notably Santiago de Cuba in 1514 and Havana in 1515.
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The engraved title page engravings made allusion to temples, caciques, and other aspects of the Americas, as well as portraits of some of the Spanish conquistadors, including his fellow cuellaranos Diego Velázquez de Cuéllar, Juan de Grijalva, and Captain Gabriel de Rojas y Córdova.
Conquistador Diego Velázquez de Cuéllar founded Havana on August 25, 1515 or 1514, on the southern coast of the island, near the present town of Surgidero de Batabanó, or more likely on the banks of the Mayabeque River close to Playa Mayabeque.