The party abandoned the colony to sail to the more prosperous colony of Santa María la Antigua del Darién, a colony established by the conquistador Vasco Núñez de Balboa without the knowledge of Nicuesa.
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In 1509, authority was granted to Alonso de Ojeda and Diego de Nicuesa, to colonize the territories between the west side of the Gulf of Urabá and Cabo de la Vela, and Urabá westward to Cabo Gracias a Dios in present-day Honduras.