Other Italian painters who had an influence on Ter Brugghen during his stay in Italy were Annibale Carracci, Domenichino and Guido Reni.
Starting thus, Sarrazin speedily obtained employment from Cardinal Aldobrandini at the Villa Aldobrandini, Frascati, where he won the friendship of Domenichino, with whom he afterwards worked on the high altar of Sant'Andrea della Valle.
His research and publications have focused on seventeenth-century European art, ranging from a two-volume catalogue raisonné on Domenichino (1581–1641) to studies based on iconographic, psychoanalytic, feminist, and economic methodologies.
He was one of the first Italian painters to paint a canvas wherein landscape took priority over figures, such as his masterful The Flight into Egypt; this is a genre in which he was followed by Domenichino (his favorite pupil) and Claude Lorrain.
He was a protégé of Cardinal Vincenzo Giustiniani, who was renowned for his patronage of painters, including Caravaggio, Nicolas Poussin and Domenichino.
The sources indicate that he was a student of Domenichino, but direct contact with the Bolognese artist is now disputed.
Borghese's collection includes works as diverse as Early Renaissance altarpieces such as Fra Angelico's Last Judgment (ca 1450); examples of northern art such as two paintings of Venus (early 16th century) by Lucas Cranach; sixteenth-century Venetian paintings such as Titian's Sacred and Profane Love (1514); and classicizing pictures such as Domenichino's Diana (1616/7).