The classical example of an antibiotic discovered as a defense mechanism against another microbe is the discovery of penicillin in bacterial cultures contaminated by Penicillium fungi in 1928.
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After working about 12 years with Allelix, Dr Kamboj joined Xenon Genetics Inc, Vancouver as its Vice President for Drug Discovery.
Because traditional methods of chemical discovery and selection relied on "natural" pathways (those formed by sources found in the wild and brought into the library), creation of the requisite number of peptides for new drug discovery was impractical.
The first industrial process was developed in Bulgaria by prof. Paskov in 1959 (Nivalin, Sopharma) from a species traditionally used as a popular medicine in Eastern Europe, and, thus, the idea for developing a medicine from these species seems to be based on the local use (i.e., an ethnobotany-driven drug discovery).
Dr. Pangalos has edited the book “Understanding G protein-coupled receptors in the CNS”, as well as a number of journal issues focused on drug discovery in the CNS.
The invention of antibody phage display by laboratories at the MRC Laboratory of Molecular Biology led by Greg Winter and John McCafferty, The Scripps Research Institute led by Richard Lerner and Carlos F. Barbas and the German Cancer Research Centre by Frank Breitling and Stefan Dübel revolutionised antibody drug discovery.
Plexxikon is a drug discovery company based in Berkeley, California, that was co-founded in 2001 by Joseph Schlessinger of Yale University with Sung-Hou Kim of the University of California, Berkeley.