He has served as a visiting scientist at the European Molecular Biology Laboratory, and the Commissariat à l'énergie atomique et aux énergies alternatives, France.
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He was a group leader in the biocomputing program at the European Molecular Biology Laboratory in Heidelberg, Germany, from 1987 to 1990; a visiting scientist at MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, between 1977 and 1990; and a professor of chemistry at Fairleigh Dickinson University in New Jersey from 1971 to 1987.
She leads research groups at the Institute of Genetics, University of Cologne and at the European Molecular Biology Laboratory in Heidelberg.
She received her PhD from Harvard Medical School and was an Associate Professor of Biochemistry at Boston University and an Associate Professor of Medicine at Harvard Medical School before transferring to the European Molecular Biology Laboratory where she replaced Klaus Rajewsky who had just gone to work at Harvard Medical School.