Along with examination of conserved synteny, conserved operon structure, or "Rosetta Stone" domain fusions, comparing phylogenetic profiles is a designated a "post-homology" technique, in that the computation essential to method begins after it is determined which proteins are homologous to which.
gene | Gene Autry | Gene Hackman | Gene Roddenberry | Gene Simmons | Gene Kelly | Gene Pitney | Gene Krupa | jazz fusion | Gene Watson | Gene Wilder | Gene Tunney | gene expression | Gene Eugene | Jazz fusion | Gene Tierney | Gene Robinson | Gene Raymond | Gene expression | Gene Deitch | Gene Clark | Gene | tumor suppressor gene | Gene Wolfe | Gene Summers | Gene Lees | Gene Harris | Gene Fullmer | Gene Ammons | nuclear fusion |
About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion gene between EML4 ('echinoderm microtubule-associated protein-like 4') and ALK ('anaplastic lymphoma kinase'), which results in constitutive kinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype.
Tyrosine kinase inhibitors such as imatinib (marketed as Gleevec) have been developed to treat chronic myeloid leukemia (CML), in which the BCR-ABL fusion gene (the product of a reciprocal translocation between chromosome 9 and chromosome 22) is present in >95% of cases and produces hyperactivated abl-driven protein signaling.