X-Nico

unusual facts about Glutamate-cysteine ligase


Glutamate—cysteine ligase

Glutamate cysteine ligase modifier subunit (GCLM, ~31 kDa) increases the catalytic efficiency of GCLC.


EGAD

Embryonic GAD, the GAD25 and GAD44 forms of glutamate decarboxylase.

Fufeng

Fufeng Group (阜丰集团), monosodium glutamate and xanthan gum producer in mainland China

Glutamate receptor

A link between glutamate receptors and autism was also identified via the structural protein ProSAP1/SHANK2 and potentially ProSAP2/SHANK3.

Glutamine oxoglutarate aminotransferase

This enzyme manufactures glutamate from glutamine and α-ketoglutarate, and thus along with glutamine synthetase (abbreviated GS) plays a central role in the regulation of nitrogen assimilation in photosynthetic eukaryotes and prokaryotes.

Metabotropic glutamate receptor

LY-341,495 and MGS-0039 are drugs that act as a selective antagonist blocking both of the group II metabotropic glutamate receptors, mGluR2 and mGluR3.

Metabotropic glutamate receptor 7

Metabotropic glutamate receptor 7 has been shown to interact with PICK1.

Monosodium glutamate

During fermentation, selected bacteria (coryneform bacteria) cultured with ammonia and carbohydrates from sugar beets, sugar cane, tapioca or molasses, excrete amino acids into the culture broth from where L-glutamate is isolated.

NFE2L2

Glutamate-cysteine ligase, catalytic (Gclc) and glutamate-cysteine ligase, modifier (GCLM) subunits form a heterodimer, which is the rate-limiting step in the synthesis of glutathione (GSH), a very powerful endogenous antioxidant.

NMDA receptor antagonist

NMDAR antagonists fall into four categories: Competitive antagonists, which bind to and block the binding site of the neurotransmitter glutamate; glycine antagonists, which bind to and block the glycine site; noncompetitive antagonists, which inhibit NMDARs by binding to allosteric sites; and uncompetitive antagonists, which block the ion channel by binding to a site within it.

SLC1A2

Ceftriaxone, an antibiotic, has been shown to induce/enhance the expression of EAAT2, resulting in reduced glutamate activity.

Stuart C. Sealfon

Gonzalez-Maeso, J., R.L. Ang, T. Yuen, P. Chan, N.V. Weisstaub, J.F. Lopez-Gimenez, M. Zhou, Y. Okawa, L.F. Callado, G. Milligan, J.A. Gingrich, M. Filizola, J.J. Meana, and S.C. Sealfon, Identification of a serotonin/glutamate receptor complex implicated in psychosis.

Synaptic plasticity

Two molecular mechanisms for synaptic plasticity (researched by the Eric Kandel laboratories) involve the NMDA and AMPA glutamate receptors.


see also