Variable surface glycoproteins allow the sleeping sickness Trypanosoma parasite to escape the immune response of the host.
INn Trypanosoma congolense, in vitro analyses of the incorporated sugars after hydrolysis of the glycoprotein showed that glucosamine and mannose are utilized in the biosynthesis of the carbohydrate moiety directly whereas galactose was converted possibly to other intermediates before being incorporated into the antigen.
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Combinatorial processes increase the diversity of variable surface glycoproteins.
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