Certain antineoplastic agents, bryostatins 4 and 5, have been extracted from Aplidium californicum and are being evaluated.
Megestrol, a progesterone derivative with antineoplastic properties used in the treatment of advanced carcinoma of the breast and endometrium
Hypericum extract, by inducing both the CYP3A4 and the P-glycoprotein (P-gp), can reduce the plasma concentrations of different antineoplastic agents such as imatinib, irinotecan and docetaxel, thus reducing the clinical efficacy of these drugs.
Currently limonoids are under investigation for a wide variety of therapeutic effects such as antiviral or Viricide, antifungal, antibacterial, antineoplastic and antimalarial.
Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus.