Holmes has performed with many celebrities as a backing vocalist, including Delta Goodrem, Westlife, UK star James Morrison, Jon Stevens, Natalie Bassingthwaighte, David Campbell, Marina Prior and with Guy Sebastian at the Australian Open Men's Tennis Finals.
In 2013 the property featured on channel 7's XFactor with Natalie Bassingthwaighte and Guy Sebastian staying on the property.
In 2006, to support Multiple Sclerosis research, Ryan teamed up with 2003 Australian Idol winner and award-winning recording artist Guy Sebastian in 7 Network's It Takes Two, in which famous accomplished Australians from their different fields, and not known to be singers, performed duets with professional vocalists to support their chosen charity.
The match is held at the end of the regular AFL season, with teams drawn mostly from retired AFL and SANFL players, augmented with a sprinkling of celebrities who over the years have included former World number 1 tennis player Lleyton Hewitt, singer Guy Sebastian and Australian media personality and actor Andrew Daddo.
Johann Sebastian Bach | Family Guy | San Sebastián | Buddy Guy | Guy's Hospital | John Sebastian | Guy de Maupassant | San Sebastian | Guy Ritchie | Guy Maddin | Guy Clark | Larry the Cable Guy | Guy Debord | Sebastian Coe | Guy | Guy Sebastian | Guy Carleton, 1st Baron Dorchester | Guy Verhofstadt | Guy Gavriel Kay | Guy Fawkes | The Fall Guy | Guy Fletcher | Guy Chambers | Sebastián Piñera | Sebastian Bach | Sebastian of Portugal | Sebastian Janikowski | Guy Sigsworth | Guy Mitchell | Guy Lombardo |
Guy Sebastian who is known to be a soul and R&B artist, sings a duet with Harvey Stuck in the Middle on his latest album Both Sides Now.
In August, 2007 soul singer Guy Sebastian recorded a tribute version of Hold On, I'm Comin at Ardent Studios in Memphis, Tennessee for his album of soul classics The Memphis Album with many of the original Stax music band members including Steve Cropper, Donald Duck Dunn, Lester Snell, and Steve Potts.
She played Guy Sebastian's love interest in the "Like it Like That" music video, as well as being in the inaugural advertising campaign for Richard Branson new V Australia Airlines.
The 2003 Australian Idol winner Guy Sebastian was also a part of the Planetshakers band for several years, taking both lead and backup vocal parts on the 2002 and 2003 albums and conferences.
During this time PLW has produced for artists such as Backstreet Boys, Human Nature, Vanessa Amorosi, Delta Goodrem, Shannon Noll, Guy Sebastian, Paulini, Marcia Hines & Ross Wilson.