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In 1548, two years after the death of Martin Luther, the Holy Roman Emperor Charles V tried to unite Catholics and Protestants in his realm with a law called the Augsburg Interim.
Under Dona Gracia, the House of Mendes dealt with King Henry II of France, Holy Roman Emperor Charles V, his sister Mary, Governess of the Low Countries, Popes Paul III and Paul IV, and Sultan Suleiman the Magnificent, Sultan of the Ottoman Empire.
Among his books, he examines the independence movements of Latin America; Ferdinand and Isabella, the Catholic Monarchs; Holy Roman Emperor Charles V, and Philip II of Spain.
It was built by architect-engineer Antonio da Sangallo the Younger of Florence, between 1527 and 1537, at the behest of Pope Clement VII who had taken refuge at Orvieto during the sack of Rome in 1527 by the Holy Roman Emperor Charles V, and feared that the city's water supply would be insufficient in the event of a siege.
In Santo Domingo, Zuazo wrote to Spanish King Charles I (Holy Roman Emperor Charles V) and William de Croÿ, Charles's chamberlain, to inform them of the hidden costs of slavery in the New World (January 22, 1518).