It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2.
::Evaluation of novel immune-based therapies using interferons, GM-CSF, G-CSF, thalidomide, IL-2, IL-12, cyclosporin (CsA), prednisone, cytotoxic agents, therapeutic immunization
TRAF3 activates ‘TANK Binding Kinase 1’ (TBK1) which activates ‘Interferon Regulatory Factor 3’ (IRF3).
In 2000 she made her PhD (with 1st class honours) from Biochemistry and Molecular biology of leukocytic and trophoblastic interferon gamma participating with University of Paris XI, Orsay, France and University of Ljubljana, Medical Faculty, Slovenia.
BRT’s tuberculosis (TB) testing is performed using the Interferon-gamma release assay T-SPOT.TB.
2003: Wolf Prize in Agriculture along with R. Michael Roberts "for discoveries of Interferon-t and other pregnancy-associated proteins, which clarified the biological mystery of signaling between embryo and mother to maintain pregnancy, with profound effects on the efficiency of animal production systems, as well as human health and well-being".
IFIT proteins (Interferon Induced proteins with Tetratricopeptide repeats) are produced in human body that are supposed to confer immunity against viral infection.
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These proteins are generally produced during viral infection, Interferon (IFN) treatment, and during pathogen recognition (Pathogen associated molecular pattern recognition) by immune system during infections.
Blood plasma levels of Interleukin 6 (IL-6), Interleukin 8, monocyte chemotactic protein-1 and Interferon-gamma were significantly increased in swine H2N3 compared to human H2N2 infected animals supporting the previously published notion of increased IL-6 levels being a potential marker for severe influenza infections.
Erythropoietin injection, under the brand name of Erykine, for anemia due to critical illness like chemotherapy, was introduced in Aug 2005 and Interferon α2b, under the brand name of Intalfa, was launched in April 2007.
Interferon beta 1b is marketed only by Bayer in the US as Betaseron and outside the US as Betaferon.
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Interferon beta 1a is sold under the trade names Avonex (Biogen Idec) and Rebif (Merck Serono), (Pfizer); CinnoVex (CinnaGen) is biosimilar.
IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells.
The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ).
EPRS is a component of the interferon-gamma-activated inhibitor of translation (GAIT) complex, which interacts with stem-loop elements (GAIT elements) in mRNAs encoding proinflammatory proteins, for example, vascular endothelial growth factor-A (VEGFA).